New International Vulvar Cancer Project Joins ACROBATIC

We are excited to welcome a new international research project to ACROBATIC. Focusing on key predictors of lymph node metastasis and recurrence in vulvar cancer, the study aims to advance more personalized and less aggressive treatment strategies. Read the full abstract below.

WP 2.30
WP leader: Liselotte Petersen Due, Kolding Sygehus, Gynecologic/Obstetric deparment.
Title: Impact of lymph vascular space invasion and tumor location on risk of lymph node metastases and recurrence in patients with vulvar cancer.
Abstract:
Purpose: This study aims to identify a subgroup of Vulva cancer (VC) patients with a low risk of lymph node metastases who may benefit from less aggressive treatment. We aim to investigate following; 1) Predictive factors of lymph node involvement and in newly diagnosed VC patients with a special focus on drainage patterns and lympho-vascular space invasion (LVSI), and 2) risk factors for metastasis in women with early-stage vulvar cancer and 3) Risk factors for regional and distant recurrence in patient with early-stage vulva cancer.
Method: The study is an international retrospective observational population-based cohort study. Study 1 is based on data from VC patients identified in the Danish Gynecological Cancer Database (DGCG). Study II and III include population-based data on VC patients identified from the Netherlands Cancer Registry (NCR) and the Swedish Quality Registry for Gynecologic Cancer (SQRGC).
Results: The overall purpose is to identify a low-risk group of VC patients who may benefit from a less aggressive treatment strategy than applied today.